abstract：:Idiopathic pulmonary fibrosis is the most common of the idiopathic interstitial lung diseases referring to the histo-pathological entity of usual interstitial pneumonia. It has been hypothesized that inflammation may trigger the multiformic fibrotic lesions found in the affected lung, and defects in the innate immune ...

journal_title：Respiratory medicine

authors： Hodgson U,Tukiainen P,Laitinen T

更新日期：2005-03-01 00:00:00

abstract：:Snoring and obstructive sleep apnoea/hypopnoea syndrome (OSAHS) are often treated with mandibular repositioning splints (MRS), but the efficacy and satisfaction of them has not been comprehensively addressed. A survey on the use of and satisfaction with MRS was posted to 177 patients referred by a hospital orthodontic...

journal_title：Respiratory medicine

authors： Izci B,McDonald JP,Coleman EL,Mackay TW,Douglas NJ,Engleman HM

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD). METHODS:Systematic review of randomized-controlled trials comparing oral theophylline with placebo for a minimum of 7 days in people with stable COPD. RESULTS:Twenty rand...

journal_title：Respiratory medicine

authors： Ram FS,Jardin JR,Atallah A,Castro AA,Mazzini R,Goldstein R,Lacasse Y,Cendon S

更新日期：2005-02-01 00:00:00

abstract：INTRODUCTION:Older patients are the most prevalent age cohort requiring bronchoscopy. Prior sedation should be offered to improve patient comfort and operator technical ease. Older patients have increased sensitivity to centrally acting drugs increasing the procedural risk. This perceived risk may limit access to bronc...

journal_title：Respiratory medicine

authors： Watts MR,Geraghty R,Moore A,Saunders J,Swift CG

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Very few studies have addressed the etiology of community-acquired pneumonia (CAP) treated in an ambulatory setting. METHODS:Patients were recruited from physicians' offices and from Emergency Rooms in Canada. Pneumonia was defined as two or more respiratory symptoms and signs and a new opacity on chest rad...

journal_title：Respiratory medicine

authors： Marrie TJ,Poulin-Costello M,Beecroft MD,Herman-Gnjidic Z

更新日期：2005-01-01 00:00:00

abstract：:Despite the growing field of interest in the role of pulmonary oxidative stress in chronic obstructive pulmonary disease (COPD), barely any data are available with respect to antioxidant capacity in the peripheral musculature of these patients. The main objective of this study was to assess in detail the antioxidant s...

journal_title：Respiratory medicine

authors： Gosker HR,Bast A,Haenen GR,Fischer MA,van der Vusse GJ,Wouters EF,Schols AM

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:To provide optimal care for patients with chronic obstructive pulmonary disease physicians need to understand if their patients benefit from an intervention. The objective of this study was to assess agreement between patients and physicians on health-related quality of life (HRQL) changes in response to r...

journal_title：Respiratory medicine

authors： Puhan MA,Behnke M,Devereaux PJ,Montori VM,Braendli O,Frey M,Schünemann HJ

更新日期：2004-12-01 00:00:00

abstract：:To document the rate and cost of antibiotic prescribing for patients diagnosed only with influenza during US ambulatory care visits. Federal survey data for 1997-2001 were used to estimate outpatient trends for all patients and healthy people age 5-49 years. Cost estimates were based on Medicare payments and Red Book ...

journal_title：Respiratory medicine

authors： Ciesla G,Leader S,Stoddard J

更新日期：2004-11-01 00:00:00

abstract：:Chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein (MCP)-1, monocyte inflammatory protein (MIP)-lalpha have been reported to play an important role in the pathogenesis of interstitial lung diseases. Among idiopathic interstitial pneumonia (IIP), ...

journal_title：Respiratory medicine

authors： Yoshioka S,Mukae H,Sugiyama K,Kakugawa T,Sakamoto N,Nakayama S,Abe K,Fujii T,Kadota J,Kohno S

更新日期：2004-10-01 00:00:00

abstract：:We aim to assess whether respiratory symptoms are associated with lung function in young adults, and whether any such relation is similar in those with asthma, in men and women, and in different countries. Study participants (aged 20-44 years) were randomly selected from the general population in 35 centres in 15 coun...

journal_title：Respiratory medicine

authors： Sunyer J,Basagaña X,Roca J,Urrutia I,Jaen A,Antó JM,Burney P,ECRHS study.

更新日期：2004-10-01 00:00:00

abstract：:Smoking cessation is the most effective way to reduce the risk of developing chronic obstructive pulmonary disease (COPD). It prevents or delays the development of airflow limitation and also reduces its progression. The objective of this study was to systematically review the effects of interventions for smoking cess...

journal_title：Respiratory medicine

authors： Wagena EJ,van der Meer RM,Ostelo RJ,Jacobs JE,van Schayck CP

更新日期：2004-09-01 00:00:00

abstract：:The aim of the present study was to investigate whether the pneumonia severity index (PSI) could adequately predict the severity of community-acquired pneumonia (CAP) and could be used as a severity of illness classification system. Furthermore, reasons that may influence the decision to admit low risk patients were a...

journal_title：Respiratory medicine

authors： van der Eerden MM,de Graaff CS,Bronsveld W,Jansen HM,Boersma WG

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To quantify persistence with inhaled corticosteroids (ICS) among new users in daily practice and identify determinants of persistence. METHODS:A retrospective cohort study was performed with data from the Dutch PHARMO system. This system consists of medication and hospital admission records of 325,000 inhabi...

journal_title：Respiratory medicine

authors： Breekveldt-Postma NS,Gerrits CM,Lammers JW,Raaijmakers JA,Herings RM

更新日期：2004-08-01 00:00:00

abstract：:Surfactant protein-A enhances the phagocytosis and killing of many pathogens, although studying this effect in an assortment of models and different experimental protocols has sometimes yielded conflicting results. In this report, using the human THP-1 cell line as the primary phagocytic cell, we systematically examin...

journal_title：Respiratory medicine

authors： Ding J,Umstead TM,Floros J,Phelps DS

更新日期：2004-07-01 00:00:00

abstract：:A multiplex polymerase chain reaction (PCR) was developed for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. Oligonucleotide primers for the amplification of the DNA of these three organisms were optimized for use in combination in the same reaction. PCR products ...

journal_title：Respiratory medicine

authors： Miyashita N,Saito A,Kohno S,Yamaguchi K,Watanabe A,Oda H,Kazuyama Y,Matsushima T,CAP Study Group.

更新日期：2004-06-01 00:00:00

abstract：:Mechanical ventilation (MV) in chronic situations is commonly used, either delivered invasively or by means of non-invasive interfaces, to control hypoventilation in patients with chest wall, neuromuscular or obstructive lung diseases (either in adulthood or childhood). The global prevalence of ventilator-assisted ind...

journal_title：Respiratory medicine

authors： Ambrosino N,Clini E

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the relationship between cephalometric parameters, upper airway morphological factors and obstructive sleep apnea (OSA) in Chinese subjects. DESIGN:Polysomnogram (PSG) were performed and scored using standard criteria. Supine lateral cephalometric parameters and pharyngeal cross-sectional areas ...

journal_title：Respiratory medicine

authors： Lam B,Ooi CG,Peh WC,Lauder I,Tsang KW,Lam WK,Ip MS

更新日期：2004-04-01 00:00:00

abstract：:The marked female predominance in cases of idiopathic chronic cough and its association with mild chronic lymphocytic airway inflammation suggests an underlying autoimmune process. We set out to test the hypothesis that idiopathic chronic cough is associated with other organ-specific autoimmune diseases in a case cont...

journal_title：Respiratory medicine

authors： Birring SS,Murphy AC,Scullion JE,Brightling CE,Browning M,Pavord ID

更新日期：2004-03-01 00:00:00

abstract：:There is a subclinical activation of coagulation and fibrinolysis system in lung cancer. Alterations in hemostatic system are seen frequently in lung cancer correlated with the prognosis of disease. In this prospective study, our purpose was to investigate the prognostic significance of hemostatic markers in patients ...

journal_title：Respiratory medicine

authors： Unsal E,Atalay F,Atikcan S,Yilmaz A

更新日期：2004-02-01 00:00:00

abstract：STUDY OBJECTIVE:Acute rejection (AR) of the allograft is a major clinical problem after lungtransplantation. Repeated episodes of AR increase the risk of developing obliterative bronchiolitis, the main cause of mortality in this patient group. It is believed that AR is caused by T-lymphocytes reacting to donor antigens...

journal_title：Respiratory medicine

authors： Ericson P,Lindén A,Riise GC

更新日期：2004-02-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) has been shown to be associated to upper airway inflammation. The object of the present study was to establish the presence of bronchial inflammation in OSAS subjects. In 16 subjects affected by OSAS, and in 14 healthy volunteers, airway inflammation was detected by the cellular...

journal_title：Respiratory medicine

authors： Salerno FG,Carpagnano E,Guido P,Bonsignore MR,Roberti A,Aliani M,Vignola AM,Spanevello A

更新日期：2004-01-01 00:00:00

abstract：:The aim of the present investigation was to evaluate the predictive value of a symptom-limited exercise test in predicting postoperative morbidity and mortality in patients submitted to pneumonectomy. The study was conducted in 150 patients (mean age, 57.1). Forty-four patients (29.3%) had postoperative complications....

journal_title：Respiratory medicine

authors： Villani F,De Maria P,Busia A

更新日期：2003-12-01 00:00:00

abstract：:The degree of risk of cross-infection of patients via lung function testing equipment has yet to be quantified. Based on current evidence, elaborate precautions are not justified for the majority of patients attending the laboratory, but attention to appropriate routine cleaning and disinfection protocols is important...

journal_title：Respiratory medicine

authors： Kendrick AH,Johns DP,Leeming JP

更新日期：2003-11-01 00:00:00

abstract：:Lung function in cases of chronic airflow obstruction (CAO) due to tuberculous destroyed lung, which is still common in Korea, has not been objectively investigated. We evaluated lung functions and postbronchodilator responses in 21 CAO patients with a forced expiratory volume in 1 s (FEV1) of 30-65% of the predicted ...

journal_title：Respiratory medicine

authors： Lee JH,Chang JH

更新日期：2003-11-01 00:00:00

abstract：:The HandiHaler is a novel breath-actuated dry powder system designed for the delivery of tiotropium 18microg daily in the treatment of COPD. We compared patient ability to use the HandiHaler or metered dose inhaler (MDI) device correctly 4 weeks after receiving brief instructions and device demonstration. A single-bli...

journal_title：Respiratory medicine

authors： Dahl R,Backer V,Ollgaard B,Gerken F,Kesten S

更新日期：2003-10-01 00:00:00

abstract：:Summary beta2-adrenoreceptor agonists are able to modulate various aspects of airway cell functions involved in the inflammatory and repair processes characterizing a variety of respiratory disorders. Human bronchial epithelial cells (HBECs), which can act as immune effector cells and express beta2-adrenoreceptors, we...

journal_title：Respiratory medicine

authors： Sabatini F,Silvestri M,Sale R,Serpero L,Di Blasi P,Rossi GA

更新日期：2003-09-01 00:00:00

abstract：:Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction (EIB). It has been shown that an in vitro hyperosmolar stimulation of basophils and mast cells with mannitol can induce the release of histamine and leukotrienes. The aim of thi...

journal_title：Respiratory medicine

authors： Moloney ED,Griffin S,Burke CM,Poulter LW,O'Sullivan S

更新日期：2003-08-01 00:00:00

abstract：:Previous studies have shown that chronic hypoxia leads to changes in skeletal muscle structure (fibre size and type) and activities of several bioenergetic enzymes. Whether this occurs also in conditions characterised by intermittent hypoxia, such as the obstructive sleep apnoea syndrome (OSAS), is unknown. To explore...

journal_title：Respiratory medicine

authors： Sauleda J,García-Palmer FJ,Tarraga S,Maimó A,Palou A,Agustí AG

更新日期：2003-07-01 00:00:00

abstract：:To clarify the clinical features of pulmonary Mycobacterium avium-intracellulare complex (MAC) infection, we retrospectively evaluated clinical manifestations, laboratory data, chest and maxillary sinus computed tomographic scans and induced sputum findings in 26 with MAC infection in comparison with 104 patients with...

journal_title：Respiratory medicine

authors： Watanabe K,Fujimura M,Kasahara K,Yasui M,Myou S,Watanabe A,Nakao S

更新日期：2003-06-01 00:00:00

abstract：:Various cells including polymorphonuclear leukocytes, alveolar macrophages and type-II pneumocytes may be a source of exhaled hydrogen peroxide (H2O2) in airways of humans. H2O2 can convert into hydroxyl radicals leading to peroxidative damage of airways structures and formation of volatile thiobarbituric acid-reactiv...

journal_title：Respiratory medicine

authors： Szkudlarek U,Maria L,Kasielski M,Kaucka S,Nowak D

更新日期：2003-06-01 00:00:00

abstract：:Several clinical trials have shown that the inhaled beta2-agonists with long-acting properties, formoterol and salmeterol, may be effective in acute exacerbations of chronic obstructive pulmonary disease (COPD). However, there is a great deal of controversy regarding the timing and optimal dose of inhaled beta2-agonis...

journal_title：Respiratory medicine

authors： Cazzola M,Santus P,Matera MG,Carlucci P,Belloli E,Di Marco F,Centanni S

更新日期：2003-05-01 00:00:00

abstract：:In developing countries, many sputum-negative suspects of pulmonary tuberculosis (PTB) are given antituberculous medication just because tuberculosis (TB) could not be excluded in them. Many studies have shown that BCG test is nearly 100% sensitive, except in those with severe malnutrition, steroid therapy and other c...

journal_title：Respiratory medicine

authors： Mathur ML,Raman S

更新日期：2003-05-01 00:00:00

abstract：:Several epidemiological studies have indicated that building dampness affects the respiratory health of the inhabitants. In this study we investigated the relationship between building dampness and respiratory symptoms in young Swedish adults. In 1993, as a part of the European Community Respiratory Health Survey stag...

journal_title：Respiratory medicine

authors： Gunnbjörnsdottir MI,Norbäck D,Plaschke P,Norrman E,Björnsson E,Janson C

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:To assess the utility of capsaicin test in the differential diagnosis of non-productive causes of chronic cough and to examine the effects of treatment on this reflex. PARTICIPANTS:86 healthy volunteers and 101 patients with chronic cough: asthma (n: 54) gastroesophageal reflux (n: 35) and post-nasal drip s...

journal_title：Respiratory medicine

authors： Nieto L,de Diego A,Perpiñá M,Compte L,Garrigues V,Martínez E,Ponce J

更新日期：2003-04-01 00:00:00

abstract：:The aim of this study was to compare the efficacy and safety of salmeterol/fluticasone propionate combination product (SFC) with fluticasone propionate (FP) plus oral montelukast (M) over 12 weeks in symptomatic asthma patients. The study was a multinational, randomised, double-blind, double-dummy, parallel-group desi...

journal_title：Respiratory medicine

authors： Ringdal N,Eliraz A,Pruzinec R,Weber HH,Mulder PG,Akveld M,Bateman ED,International Study Group.

更新日期：2003-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a condition characterized by progressive airflow limitation, with symptoms of dyspnoea, cough, and sputum production. Aside from information on prevalence, mortality and hospital resource utilization arising from COPD in Canada, there is a lack of data on the impact of t...

journal_title：Respiratory medicine

authors： Chapman KR,Bourbeau J,Rance L

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature. AIM:To estimate the prevalence of COPD as defined by British Thoracic Society (BTS) criteria and the recent global initiative for chroni...

journal_title：Respiratory medicine

authors： Lundbäck B,Lindberg A,Lindström M,Rönmark E,Jonsson AC,Jönsson E,Larsson LG,Andersson S,Sandström T,Larsson K,Obstructive Lung Disease in Northern Sweden Studies.

更新日期：2003-02-01 00:00:00

abstract：:The fraction of the emitted dose from an inhaler that has the potential to be deposited into the lungs is known as the fine particle dose (also the respirable dose). During inhalation all dry powder inhalers require a 'force' to be created inside the device so that a fine particle dose is generated from the formulatio...

journal_title：Respiratory medicine

authors： Chrystyn H

更新日期：2003-02-01 00:00:00

abstract：:Inhalation of organic dust from a swine-confinement building leads to an intense inflammatory reaction with an increased number of inflammatory cells and mediators in the upper and lower respiratory tract of previously unexposed subjects. In vitro the dust induces cytokine release from epithelial cells and alveolar ma...

journal_title：Respiratory medicine

authors： Burvall K,Palmberg L,Larsson K

更新日期：2003-01-01 00:00:00

abstract：:Viozan (sibenadet HCl, AR-C68397AA) is a novel dual D2 dopamine receptor, beta2-adrenoceptor agonist that has been investigated for efficacy in alleviating the symptoms of chronic obstructive pulmonary disease (COPD). The slowly progressive nature of this disease means that patients will require ongoing therapeutic ma...

journal_title：Respiratory medicine

authors： Hiller FC,Alderfer V,Goldman M

更新日期：2003-01-01 00:00:00